Pyroluria & Pyrrole Disorder

About Pyroluria & Pyrrole Disorder

Pyroluria, also commonly called pyrrole disorder, pyrroles, kryptopyrroles, kryptopyrroluria (KPU), haemopyrrollactamuria (HPL) or Mauve Factor, is a condition that may be associated with anxiety, poor stress tolerance and outbursts of anger or aggression among a number of other symptoms.

Pyroluria is understood to involve an abnormality in haemoglobin synthesis, resulting in the production of excessive amounts of waste products called pyrroles.

We expect the general population when tested have less than 10mcg/dL, however, elevated pyrrole patients may experience levels above 15-20mcg/dL, including extremely elevated levels of above 100mcg/dL.

Pyroluria and pyrroles are understood to deplete the body of important nutrients, including vitamin B6, zinc, biotin, magnesium and omega 6 GLA/AA.
Vitamin B6 and zinc, in particular, are understood to be essential for daily happiness, stress-coping and a stable mood even when things go wrong as they may affect our serotonin, glutamate and GABA neurotransmitters.

Symptoms which may be associated with an elevated pyrrole level include:

  • Anxiety, including fear or fearfulness.
  • Poor stress tolerance and difficulty coping with stressful situations.
  • Outbursts of anger, aggression, or an explosive temper.
  • Poor coping with changes in routine, and anxiety in new situations.
  • Sudden changes in mood and emotional lability.
  • Poor short-term memory.
  • Absence of dream recall, not remembering dreams.
  • Sensitivity to light, noise or smells.
  • Poor immune function.

An elevated pyrrole level may be associated with children and adults with anxiety, autism, ADD/ADHD, schizophrenia, Down syndrome, epilepsy, depression, bipolar disorder, and even criminal behaviour and substance abuse.

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